Gliclazide treatment lowers serum ICAM-1 levels in poorly controlled type 2 diabetic patients.
نویسندگان
چکیده
OBJECTIVE To investigate the potential effect of gliclazide on serum ICAM-1 (intercellular adhesion molecule-1) and VCAM-1 (vascular cell adhesion molecule-1) levels in poorly controlled type 2 diabetic patients. PATIENTS AND METHODS The study included 104 patients, randomly divided into two groups. Group A comprised 53 patients (26 men) treated with gliclazide with a mean age of 67.5+/-9.9 years, a mean diabetes duration of 13.4+/-5.4 years and a mean HbA1c of 8.6+/-1.1%. Group B comprised 51 patients (25 men) treated with glibenclamide with a mean age of 66.4+/-10.9 years, a mean diabetes duration of 13.2+/-6.1 years and a mean HbA1c of 8.4+/-1.3%. A third group of 30 healthy controls (15 men) with a mean age of 63.3+/-10.4 years was also included. Serum levels of ICAM-1 and VCAM-1 were measured at the beginning of the study and after six months of treatment. RESULTS Pretreatment serum ICAM-1 and VCAM-1 levels did not differ between groups A and B, while they were significantly higher (P=0.0001) than in healthy controls. No significant difference in HbA1c, body mass index, blood pressure control and lipid profile between the two groups was observed after the sixth month of treatment. In group A, serum ICAM-1 levels after six months of treatment were significantly reduced from 623.12+/-61.17 ng/ml to 370.14+/-49.92 ng/ml (P=0,01), while no reduction was found in VCAM-1 levels. In group B, no reduction was found in serum ICAM-1 and VCAM-1 levels after the end of the study. CONCLUSIONS Our results suggest that gliclazide treatment reduces serum ICAM-1 levels in poorly controlled type 2 diabetic patients. This reduction is independent of the hypoglycaemic action of gliclazide.
منابع مشابه
Association of Serum Ferritin Levels with Glycemic Control in type-2 Diabetes Mellitus
Several recent studies concluded that, serum ferritin was found to be high in uncontrolled type 2 diabetic patients. There is paucity of information regarding association of serum ferritin levels with glycemic control in type 2 diabetic patients in India. This study was undertaken to identify the serum ferritin levels in poorly controlled type 2 diabetic patients and in well controlled type 2 d...
متن کاملEffects of Folic Acid Supplementation on Proteinuria in Type 2 Diabetic Patients with Overt Proteinuria
Objective: An association between high homocysteine levels and proteinuria in diabetic nephropathy has been shown. On the other hand, supplementation with folic acid lowers homocysteine concentration. We have studied the effects of folic acid supplementation on proteinuria in type 2 diabetic patients with overt proteinuria. Materials and Methods: Forty five (29 men and 16 women) type 2 diabe...
متن کاملComparison of Gliclazide Treatment with Diet Therapy on Acute Phase Protein Levels in Patients with Type 2 Diabetes*
Aims: It is known that there is a relationship between diabetic complications and chronic inflammation characterized by alterations in circulating acute phase proteins. It has been emphasized that inflammation contributes to diabetic complications and that gliclazide -an antidiabetic sulfonylurea decreases the development of such complications. In this study, we aimed to investigate whether gli...
متن کاملComparison of nateglinide and gliclazide in combination with metformin, for treatment of patients with Type 2 diabetes mellitus inadequately controlled on maximum doses of metformin alone
AIM To compare the effects of nateglinide plus metformin with gliclazide plus metformin on glycaemic control in patients with Type 2 diabetes. METHODS Double-blind, double-dummy, parallel group, randomized, multicentre study over 24 weeks. Patients with inadequate glucose control on maximal doses of metformin were randomized to additionally receive nateglinide (n = 133) or gliclazide (n = 129...
متن کاملاثر تخم شنبلیله بر فاکتورهای متابولیکی سرم و سطوحIntercellular adhesion molecule1))ICAM-1 در بیماران دیابتی نوع 2
Background and Objectives: Diabetes mellitus (DM) especially type2 is one of the main causes of morbidity in developing countries such as Iran. Recently, fenugreek seeds as medical plant have been considered for treatment of diabetes. Therefore, we conducted this study to evaluate the effects of fenugreek seeds on serum metabolic factors and ICAM-1 levels in type 2 diabetic patients. Materials ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Diabetes & metabolism
دوره 32 4 شماره
صفحات -
تاریخ انتشار 2006